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Blood and Serum Fractions

The retention of bacteria, mycoplasma, endotoxins, and other undesired pollutants in serum and plasma is accomplished using our tested filters. Your filters' configuration versatility ensures that they will have the ideal mix of media, layers, and pore sizes depending on the fluid's composition and pollution levels.

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Blood products are various human plasma protein products, including human blood albumin, human placental blood albumin,immunoglobulin, and so on. The raw material of blood products is plasma. Human plasma 92%-93% is water, only 7%-8% is protein, blood products are made from this part of the protein separation and purification.

blood components
BLOOD AND SERUM FRACTIONS

Challenges in the production of blood products

In the production process of blood products, it is important to ensure that the conditions are gentle, so that all types of proteins are not inactivated and denatured, and that the damage to plasma proteins is minimized as much as possible. In the production process of blood products, pathogens must be inactivated or removed, but there are some shortcomings in the commonly used methods of inactivating and removing viruses.

 

Maintaining mild production conditions is essential to prevent inactivation and denaturation of proteins. By using mild process conditions, damage to plasma proteins is minimized to ensure the bioactivity and quality of the product.

At the same time, a well-designed process is important important to ensure the safety and quality of blood products. It includes multiple stages such as clarification pretreatment of plasma raw materials, filtration steps, chromatography, ultrafiltration, etc. to ensure proper control and monitoring at each step.

Process Flow for the Production of Blood Products

Filtration Process Recommend Product Recommend Pore Size
Pre-filtration Ultrapure Capsule Filter 1~10um
Ultrapure Cartridge Filter 1~10um
Final sterilization filtration Stery Series 0.1~0.22um
Integrity testing Filter Integrity Tester S1.0 Filter Integrity Tester S1.0

Prefiltration

Since blood contains a large number of microorganisms and impurities, and is very easy to combine with proteins, in order to ensure the purity and safety of blood products, after obtaining plasma raw materials, it is usually necessary to carry out preliminary filtration, which is an easier step compared with the de-viralization filtration and chromatography. Gums, aggregates, non-target proteins, lipids, and particles are removed prior to downstream purification and protection of downstream sterilizing filters or columns.

A simple primary filtration step to obtain a crude liquid is usually performed using filters that remove particles and have a high retention rate. The Ultrapure series of membrane pleated cartridges offer extremely high filtration efficiency and absolute precision filtration for particles ranging from 0.10 µm to 100 µm, and these cartridges have a filtration efficiency of up to 99.9% at specified pore sizes, ensuring reliable and efficient filtration performance. They also protect downstream sterilizing filters for longer service life.

buffy coat method

Sterilization filtration

The purpose of sterilization filtration is to control the level of microorganisms during the production of blood products. Sterilization filtration is a process that removes microorganisms from a liquid stream without negatively affecting the quality of the product itself, utilizing physical retention to remove bacteria from the liquid or air clock in order to achieve sterility.

Throughout the process, terminal filtration is often carried out using membranes with a pore size of 0.22 μm to ensure product safety and efficiency, enabling dispensing of the sterilized product.

The Stery series of cartridge filters not only provide excellent microbial retention, but are also cost effective and can be sterilized using steam or hot water to extend service life and reduce replacement costs.The Stery series of cartridge filter are available in a wide variety of sizes and sizes, and are available in a wide range of sizes and sizes.

What Sanitek can do in this procedure?

By ensuring the functionality and durability of your equipment, Sanitek’s tailored filtration solutions contribute to long-term cost savings on maintenance and operational expenses.

Sanitek’s market-leading filtration systems specialize in the removal of oil and particles from water streams, addressing environmental regulations or injection well standards. Our innovative offerings encompass oil adsorptive guard filters, high-efficiency coalescers, as well as disposable and washable solid cartridge solutions.

For this specific application, Sanitek designs and manufactures filter cartridges and filter housings. Our Oltek pleated filter cartridge and Oltek string wound filter cartridge stand out as ideal solutions for maintaining the required purity levels in this condition.

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