Compatibility with Filter Housings
The selection of the gasket/O-ring and end cap configuration determines the compatibility of the filter element with the filter housing. The most important considerations when selecting a gasket/O-ring are chemical compatibility, temperature, and service life.
Buna-N (nitrile butadiene) is a standard option that provides a good seal for many fluids but is susceptible to more aggressive chemicals. However, it is resistant to petroleum-based fuels.
EPDM (or ethylene propylene) has excellent ozone resistance and is typically used in FDA-regulated processes in the pharmaceutical industry to hold shape and maintain it for longer periods.
Silicones can hold their shape and seal for long periods. They are effective above 400°C and across a wide range of chemicals.
Polytetrafluoroethylene or polytetrafluoroethylene (PTFE) gaskets are extremely abrasion and corrosion resistant. They offer optimum chemical compatibility in the process of pharmaceutical filtration.
Viton or fluoroelastomer has excellent sealing properties and works well with gases, fuels and many organic chemicals. It performs well at high temperatures, but low temperatures can cause hardening and negatively affect the seal.
Liquid Filter Cost Considerations
Finally, the cost of the filter needs to be considered, which includes materials and costs associated with maintenance and replacement. Capsule filters are single-use Capsule filters suitable for filtration of small amounts of medicinal liquids, with little residue and loss, and are easy to install.
They can be sterilized off-line. Cartridge filters are low cost and can be sterilized in-line or off-line. According to the filtration requirements, combined with the previous items, considering the budget can choose different filtration programs.
Conclusion
Filtration is a basic requirement in pharmaceutical manufacturing, and appropriate filters are used at multiple points in the liquid filtration process for pharmaceuticals.
By considering the type of liquid, filtration requirements, filter type, filter material, existing system fit and cost, you can select a filter that meets your specific needs and provides efficient and cost-effective filtration.
Sanitek offers a full line of filtration products for the pharmaceutical industry, including capsule filters, cartridge cartridges, lenticular filter, filter housings and more. If you are unsure of the type of filter you need, please contact our technical experts and we will assist you within 24 hours.