Purpose of prefiltration and sterilization
For the preparation of blood products, processes such as filtration and chromatography are particularly important. Specifically, the target plasma proteins can be obtained step by step through preliminary filtration, multistage precipitation and filtration, chromatography, and ultrafiltration concentration. And in the preparation of blood products, the pretreatment of plasma and the final terminal filtration, as the first and last step, should not be underestimated.
Pre-filtration
Since blood contains a large number of microorganisms and impurities, and is very easy to combine with proteins, in order to ensure the purity and safety of blood products, after obtaining plasma raw materials, it is usually necessary to carry out preliminary filtration, which is an easier step compared with the de-virtualization filtration and chromatography. Gums, aggregates, non-target proteins, lipids, and particles are removed prior to downstream purification and protection of downstream sterilizing filters or columns.
A simple primary filtration step to obtain a crude liquid is usually performed using filters that remove particles and have a high retention rate. The Ultrapure series of membrane pleated cartridges offer extremely high filtration efficiency and absolute precision filtration for particles ranging from 0.10 µm to 100 µm, and these cartridges have a filtration efficiency of up to 99.9% at specified pore sizes, ensuring reliable and efficient filtration performance. They also protect downstream sterilizing filters for longer service life.
Sterilization Filtration
The purpose of sterilization filtration is to control the level of microorganisms during the production of blood products. Sterilization filtration is a process that removes microorganisms from a liquid stream without negatively affecting the quality of the product itself, utilizing physical retention to remove bacteria from the liquid or air clock in order to achieve sterility.
Throughout the process, terminal filtration is often carried out using membranes with a pore size of 0.22 μm to ensure product safety and efficiency, enabling dispensing of the sterilized product.
The Stery series of cartridge filters not only provide excellent microbial retention but are also cost-effective and can be sterilized using steam or hot water to extend service life and reduce replacement costs. The Story series of cartridge filters are available in a wide variety of sizes and sizes and are available in a wide range of sizes and sizes.