Prefiltration/ Clarification
Pre-filtration usually refers to the first step in the filtration process, aiming to remove large impurities or particles in the feed liquid, requiring the filter to carry a large amount of pollution and a high flow rate at low pressure difference. At the same time, the installation of the pre-filter can also protect the downstream filter, improve the service life of the downstream filter, and reduce the total cost. It varies according to the media of the pre-filter, the chemical properties of the feed liquid, the throughput and the sterilization conditions, etc..
Each pre-filtration application has specific requirements, with a single filter for single layer media, a single filter for multiple layers of media, or multiple filters in series.If the size of the particulate matter in the filtered media is clear, the single-layer filter is sufficient; If the composition of the impurities in the filtered media is more complex, it may be necessary to use multi-layer pleated filters or multiple single-layer filters in series, typically these filters called depth filter made from polypropylene or fiberglass.
SANIpure® PP filters
SANIpure® PP series adopts high quality polypropylene media, with nominal precision single layer , multi-layer pleated and absolute precision single layer three media to choose from, to meet the needs of different pre-filtration applications. The structure of the full polypropylene provides good chemical compatibility and is suitable for the filtration of most feed liquids.SANIpure® PP series have excellent performance, combined with high dirt holding capacity, high flow rate at low pressure drop and long service life, resulting these cost-efficient filters.
Available Formats
SANIpure® GF filters
The SANIpure® GFS prefilter are composed of fine glass microfiber with high dirt holding. This combination provides the filter with an inherently absorptive characteristic that enhances filter retention capacity. They are highly recommended for the filtration of liquids containing gels, lipids and proteins.
Available Formats
Metal Filtration/ Clarification
Stainless steel filter element has very good filtration performance, the main filter material adopts multi-layer stainless steel sintered mesh, folded sintered felt, folded wire mesh, sintered stainless steel powder and titanium powder etc., the filtration accuracy is 0.5-200um, and its dimensions can be processed according to user requirements.
Stainless steel filter element is resistant to high or very low temperature, optional porosity of 28%-50% , optional accuracy of 0.2um – 100um; Good corrosion resistance，is suitable for a variety of acid, alkali and other corrosive media and sulfur-containing steam. And the stainless steel filter element has high strength and good toughness, which is suitable for harsh high-pressure and high-temperature conditions. After repeated cleaning and regeneration, the filtration performance is restored to 90%.
SANITEK offers four types of stainless steel filters: CSSM® with muti-layer 316 or 304 stainless steel mesh, PSF® with stainless steel fiber sintered felt, PSM® with woven stainless steel mesh ,and PSM® with Titanium sintered. These filters are usually used for the decarbonization of pharmaceutical liquids, the decontamination of disinfecting water, and steam filtration in the biopharmaceutical industry.
Available Formats
Sterile Liquid Filtration
Sterilization grade filtration is a “cold” sterilization method that differs from traditional heat sterilization in that it aims to remove microorganisms through the filtration membrane rather than kill them. For some biological products or reagents that cannot be used for heat treatment, filtration sterilization is the only and most important way to remove bacteria.
The membrane medias of the sterilizing filters usually have PES, PVDF,Nylon6,6, and CA, and these medias are usually stable in nature and do not react with the feed liquid. However, for some special solutions, such as protein solutions, there may be a problem of protein adsorption by the membrane, so PVDF with low protein adsorption can be tselected. Therefore, the appropriate degerming filter should be selected according to the different degerming application.
SANIpore® PES filters
SANIpore® PES series is an efficient bactericidal removal series, equipped with bioburden reduction, sterilizing, double-layer sterilizing membrane medias.These folding filter has the characteristics of ultra-low protein adsorption, dissolution/precipitation level, uniform pore size distribution, excellent bacterial retention ability, and excellent initial flux. This makes it the ideal filter to ensures bio-burden or sterilizing and small particle removal in a wide range of biological liquids, and intermediate bulk pharmaceutical fluids. 0.1 μm rated filter cartridges are especially developed for validated sterile filtration and reliable mycoplasma removal from any media.
Available Formats
SANIpore® Nylon6,6 filters
Nylon6,6 membrane filter is a widely used filter medium made of nylon6,6 media, mainly used to separate and filter particles and impurities from the liquid, remove microorganisms from the filter liquid. Nylon6,6 microfiltration membrane has the characteristics of natural hydrophilicity, chemical resistance (dilute acid, dilute alkali, alcohol, oil, hydrocarbons, and other organic inorganic compounds), high strength, high temperature resistance (up to 90℃), high flow rate, wide aperture range, etc., suitable for sterile filtering and intercepting impurities of various sizes. Nylon6,6 membranes filters are the ideally used in a variety of pharma, biopharma and chemical industrial applications, where they can be sterilized by autoclaving, gamma radiation, and other methods, making them suitable for sterile filtration applications.
Available Formats
SANIpore® PTFE filters
PTFE membranes are naturally hydrophobic, making them the best choice for gas filtration. PTFE microporous membrane has the characteristics of smooth surface, chemical resistance, air permeability, water permeability, flame retardant, high temperature resistance, strong acid and alkali resistance, non-toxic, etc., can be widely used in a variety of gas filtration and strong organic solvent filtration. And the running resistance is low, the filtering speed is fast; Long service life, reusable, thus reducing operating costs.
PTFE membranes can also be modified by surface, from hydrophobic to hydrophilic, suitable for the filtration of some hydrophilic highly corrosive liquids, such as disinfectants, strong oxidizing solvents, strong acids or strong alkalis.
Available Formats
SANIpore® PVDF filters
PVDF membrane has a variety of properties, so that it is widely used in fine chemistry, biomedicine, food and beverage and other fields. PVDF medium mainly has the following characteristics: good chemical corrosion resistance and temperature resistance, can withstand most chemicals and poor working conditions; Ultra-low protein adsorption, can be used to filter precious protein solutions; High biocompatibility, no cytotoxicity, can be used in harsh filtration processes; High tensile strength, durable, provide long service life.
SANITEK offers hydrophilic, high-performance PVDF pleated element filters that are particularly suitable for debacterialization filtration in the biopharmaceutical industry.
Available Formats
Vent/Gas Filtration
As one of the main components of the public system in industrial production, the quality of gases determines the cleanliness and production security of the entire factory, so gases filtration plays a very important role in industrial production especially in biomedical industry.
Taking respirator for example:
For liquid storage tanks or reaction tanks, a respirator is necessary to maintain the pressure balance in the tank. When the liquid in the tank is filled, the air in the tank must be discharged; In contrast, when the tank liquid is emptied, the lost liquid volume must be compensated by air or gas. Therefore, the air or gas entering the tank must be aseptic to ensure that the feed liquid is not contaminated. Usually, hydrophobic membranes are used for gas filtration, such as PTFE, which can also reduce the risk caused by bacteria in the wet element filter while efficiently removing bacteria.
Available Formats
Endotoxin Removal Filtration
Endotoxin is mainly derived from the outer cell wall of Gram-negative bacteria. Because endotoxin can firmly bind to the cell wall, it is usually released only after the death of the bacteria and the cell wall is dissolved. Therefore, it is widely found in nature, including tap water, air, and even food. Endotoxin in any way into the human body will cause harm to the human body, not only through the digestive tract, so the market of injections, oral medicine and chemicals, medical devices, etc., must go through a strict endotoxin free test.
The surface of the specially modified positively charged NY6,6 membrane can absorb the negatively charged endotoxins, viruses and cells in the fluid through static electricity. SANIendo® series filter is an excellent choice for pharmaceutical and bio-processing applications to remove endotoxin.
