Construction of Materials
| Filter Membrane | Polyethersulfone |
| Media Support | Polypropylene |
| End Caps | Polypropylene |
| Inner Core | Polypropylene |
| Outer Cage | Polypropylene |
| Sealing Method | Thermal Bonding |
SANIpore® DS Capsule Filter
Double-layer hydrophilic PES membrane
SANIpore® DS filter cartridges feature a dual-layer hydrophilic polyethersulfone (PES) membrane, offering both high throughput and reliable microbial retention. Designed for critical applications, they can be repeatedly sterilized with steam or hot water, extending service life and helping reduce replacement costs. This balance of performance and cost-efficiency makes them suitable for final filtration of vaccines, biologics, and fermentation liquids.
PES Capsule Filters with Staubli Connection
Capsule filters incorporate a single-layer hydrophilic PES membrane and a Staubli vent connection, enabling online integrity testing. With broad chemical compatibility and low protein binding, the capsules are ideal for the filtration of sensitive or high-value products such as biologics and vaccines. Constructed entirely from polypropylene without adhesives, binders, or surfactants, each unit is DI-water rinsed to minimize extractables and reduce process downtime. The hydrophilic PES membrane does not require pre-wetting, supporting efficient, contamination-free startup in small-scale or single-use systems.
Features and Quality
- Hydrophilic PES membrane for fast wet-out and consistent performance
- Broad chemical compatibility for diverse process fluids
- High flow rates with low differential pressure
- Low extractables to minimize risk of product contamination
- Fully disposable capsule format for easy use and integration
- Compact design ideal for small-scale or single-use applications
- Compatible with online integrity testing (Staubli connection available)
Typical Applications
- Bioburden and sterile filtration in bioprocessing
- Filtration of injectables, vaccines, and biologics
- Final filtration of APIs, buffers, and ophthalmics solutions
- Clarification and filtration of protein-based solutions
- Disinfectant and cleaning fluid filtration
- High-purity water filtration
- Filtration of wine, beer, and spirits
Cartridge Integrity Test Specifications
| Pore size | Min. Bubble Point | Diffusive Flow |
| 0.1um | 2.0barg@22℃/IPA | ≤28ml/1.3barg |
| 0.2um | 3.8barg@22℃ | ≤28ml/2.8barg |
| 0.45um | 2.7barg@22℃ | ≤25ml/1.7barg |
Features and Quality
Features and Quality
- Hydrophilic PES membrane for fast wet-out and consistent performance
- Broad chemical compatibility for diverse process fluids
- High flow rates with low differential pressure
- Low extractables to minimize risk of product contamination
- Fully disposable capsule format for easy use and integration
- Compact design ideal for small-scale or single-use applications
- Compatible with online integrity testing (Staubli connection available)
Specification and Data
Construction of Materials
| Filter Membrane | Polyethersulfone |
| Media Support | Polypropylene |
| End Caps | Polypropylene |
| Inner Core | Polypropylene |
| Outer Cage | Polypropylene |
| Sealing Method | Thermal Bonding |
Cartridge Integrity Test Specifications
| Pore size | Min. Bubble Point | Diffusive Flow |
| 0.1um | 2.0barg@22℃/IPA | ≤28ml/1.3barg |
| 0.2um | 3.8barg@22℃ | ≤28ml/2.8barg |
| 0.45um | 2.7barg@22℃ | ≤25ml/1.7barg |
Ordering Information
Support for Drug Product Applications
Our PES capsule filters and filter cartridges are well-suited for the sterile filtration of drug products such as injectables, vaccines, and biologics. The hydrophilic PES membrane offers low protein binding and broad chemical compatibility, making it ideal for use in critical drug manufacturing steps.
The filter design supports industry-standard validation studies, including:
- Filter integrity testing
- Bacterial retention (BRT)
- Chemical compatibility
- Extractables and leachables (E&L)
- Throughput and capacity testing
Common questions about Sanitek
What is the difference between PES and PVDF filter membranes?
What is the difference between PES and PVDF filter membranes?The main difference lies in their chemical compatibility and filtration properties. PES (polyethersulfone) membranes offer excellent compatibility with a broad range of solvents, acids, and bases. They are known for their low protein binding and high flow rates.
PVDF (polyvinylidene fluoride) membranes, on the other hand, have superior chemical resistance, making them suitable for aggressive solvents and strong acids. PVDF membranes also provide high protein binding capacity, making them ideal for protein-based applications. The choice between PES and PVDF depends on the specific requirements of the filtration process, including chemical compatibility and protein retention needs.
How do you guarantee the quality of your filters?
All materials meet the specifications for biological safety per USP Class V1-121 C for plastics. Materials of construction comply with FDA regulations for food and beverage contact use as detailed in the US Code of Federal Regulations, 21 CFR. Materials used to produce filter media and hardware are safe for use in contact with foodstuffs in accordance with EU Directives 10/2011.
Are these filters compatible with aggressive chemicals?
Our PES membrane offers broad chemical compatibility, making it suitable for use in a wide range of process fluids, including solvents, acids, and buffers commonly used in pharmaceutical and biopharmaceutical applications.
What is the recommended operating pressure for these filters?
The recommended operating pressure for our PES filters varies depending on the specific model, but generally, our filters are designed for low differential pressures to ensure high flow rates while minimizing the risk of membrane damage.
What sizes and configurations are available for PES filter capsules?
Our PES filter capsules are available in a range of sizes and configurations to meet different flow rate and filtration area requirements. Whether for small-scale lab experiments or large-scale production, we offer solutions tailored to your specific needs.
Can these filters be used for the filtration of both liquids and gases?
Yes, our PES filter capsules and cartridges are versatile and can be used for both liquid and gas filtration. Their broad chemical compatibility and reliable performance make them suitable for various applications, including sterile air and liquid filtration.
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